PERINDOPRIL Russian patent published in 2008 - IPC C07K5/62 A61K38/05 A61P9/00

Abstract RU 2339645 C2

FIELD: chemistry.

SUBSTANCE: formula (I) is obtained from protected precursor compound of the formula (II) , where R is carboxy protective group. Method involves protection removal from COOR carboxylic group linked to heterocyclic ring in the formula (II), thus obtaining respective free acid. Protection removal is performed in the presence of an alkali forming pharmaceutically acceptable salt with the indicated free acid and, if necessary, is followed by hydration of pharmaceutically acceptable perindopril salt.

EFFECT: improved method of perindopril obtainment.

15 cl, 1 dwg, 1 tbl, 7 ex

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RU 2 339 645 C2

Authors

Rao Dkharmaradzh Ramachandra

Kankan Radzhendra Narajanrao

Dates

2008-11-27—Published

2003-11-18—Filed