FIELD: chemistry.
SUBSTANCE: invention relates to a novel crystalline form of perindopril of formula I: 
. Also proposed are methods for synthesis of amorphous and crystalline perindopril using starting substance in form of stereospecific amino acid, N-[(S)-carbethoxy-1-butyl]-(S)-alanine, which is protected by a trimethylsilyl group and converted to reactive acid chloride using thionyl chloride or its complex with 1-H-benzotriazole (1:1), which reacts with (2S, 3aS, 7aS)-octahydroindole-2-carboxylic acid, having a protected carboxy group. The invention also relates to a pharmaceutical composition based on the said crystalline form of perindopril.
EFFECT: novel form of perindopril is obtained, which can be used in medicine for treating cardiovascular diseases.
8 cl, 4 dwg, 7 ex
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