FIELD: chemistry.
SUBSTANCE: nitroxy-derivatives or their salts of general formula (I) R-NR1c-(K)k0-(B)b0-(C)c0-NO2, where c0 represents 1; b0 represents 0; k0 represents 0 or 1; R represents radical of pain-killing agent of formula (II) 
where: W represents carbon atom; m represents integer from 0 to 1; R0=H or -(CH2)n-COOH, where n represents integer from 0 to 2; R2 with R1 and with W together form saturated ring C6; R1c represents H; K represents (CO); C represents two-valent radical, having formula -Tc-Y-, where Tc=(CO) or O; or Y can be: alkylenoxy group -R'O-, in which R' represents straight-chain or branched C1-C20alkyl, or group of formula 
where n3 represents integer from 0 to 5 and n3' represents integer from 1 to 3. Also described are pharmaceutical composition based on nitroxy-derivatives and their application as medications for chronic pain treatment.
EFFECT: useful biological properties of compounds.
8 cl, 3 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NITROOXY-DERIVATIVES OF CYCLOOXYGENASE-2 INHIBITORS | 2003 |
|
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| NITROOXYDERIVATIVE STEROIDS | 2006 |
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| CRYSTALLINE FORM OF (-AMINOBUTYRIC ACID ANALOGUE | 2004 |
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| AZASPIRO-COMPOUNDS FOR PAIN TREATMENT | 2003 |
|
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| STEROID COMPOUND, PHARMACEUTICAL COMPOSITIONS | 2000 |
|
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| NITROOXY-DERIVATIVES OF LOSARTAN, VALSARTAN, CANDESARTAN, TELMISARTAN EPROSARTAN AND OLMESARTAN AS BLOCKERS OF ANGIOTENSIN II RECEPTORS FOR TREATING CARDIOVASCULAR DISEASES | 2004 |
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RU2320369C2 |
