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2 341 517

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IPC

C07D213/81(2006-01-01)

C07D213/82(2006-01-01)

(21) (22)

Application

2005128537/04, 2005-09-14

(24)

Start date

2005-09-14

(22)

Actual filing date

2005-09-14

(45)

Published

2008-12-20

(72)

Inventor

Garanin Viktor AleksandrovichEremenko Leonid TimofeevichKosilko Vera PavlovnaNesterenko Dmitrij Aleksandrovich

(73)

Holder

Nekommercheskaja Organizatsija Uchrezhdenie Institut Problem Khimicheskoj Fiziki Rossijskoj Akademii Nauk Gosudarstvennogo Uchrezhdenija Ran)

METHOD OF OBTAINING N-(2-NITROXYETHYL)NICOTINAMIDE FROM ETHYLNICOTINATE Russian patent published in 2008 - IPC C07D213/81 C07D213/82

Abstract RU 2341517 C2

FIELD: chemistry.

SUBSTANCE: described is method of obtaining N-(2-nitroxyethyl)nicotinamide (nicorandyl) of formula by nitrating intermediate N-(2-hydroxyethyl)nicotinamide, which, in its turn, is obtained by interaction of ethylnicotinate with excess of monoethanolamine, differing by the following: reaction is carried out in ethanol and output of N-(2-hydroxyethyl)nicotinamide is brought up to quantitative.

EFFECT: increase of nicorandyl output from 83-84% to 94% and reduction of wastes amount.

1 cl, 2 ex

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RU 2 341 517 C2

Authors

Garanin Viktor Aleksandrovich

Eremenko Leonid Timofeevich

Kosilko Vera Pavlovna

Nesterenko Dmitrij Aleksandrovich

Dates

2008-12-20—Published

2005-09-14—Filed