METHOD OF OBTAINING OPTICALLY ACTIVE 5-METHOXY-2-((4-METHOXY-3,5-DIMETHYLPYRIDIN-2-YL)METHYLSULFINYL)-1H-BENZO[d]IMIDAZOLE Russian patent published in 2008 - IPC C07D401/12 

FIELD: chemistry.

SUBSTANCE: obtaining optically active 5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazole, demonstrating anti-ulcer activity, by enantioselective oxidation by organic proxides of 5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methyltio)-1H-benzo[d]imidazole in presence of catalyst in organic solvent, as catalyst, preliminary obtained in situ complex of vanadium salt with chiral Shiff base, described by general formulas III and IV, , is used, substituents R₁, R₂, R₃, R₄ can be similar or different and can be hydrogen atom, alkyl group (including ones which contain halogen atoms), alkyloxy group (including ones containing halogen atoms), nirtogroup, dialkylamino group, halogen; R₅ is optically active substituent; reaction is carried out at reduced temperature with possible presence of organic base with further product isolation by usual methods.

EFFECT: novel compounds possess useful biological properties.

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