METHOD OF OBTAINING ESOMEPRAZOLE Russian patent published in 2008 - IPC C07D401/12 C07D235/28 A61K31/415 

Abstract RU 2339631 C1

FIELD: chemistry.

SUBSTANCE: method lies in enantioselective oxidation with organic peroxides of (S)-5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylthio)-1H-benzo[d]imidazole in presence of catalytic complex of titanium (IV) with simultaneously two chiral ligands: chiral diol (preferably D-diethyltartrate) and chiral amine (preferably N,N-dimethyl-(R)-1-phenylethylamin).

EFFECT: increase of target product or its salt output.

1 cl, 1 dwg, 4 ex

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RU 2 339 631 C1

Authors

Khomenko Tat'Jana Mikhajlovna

Volcho Konstantin Petrovich

Salakhutdinov Nariman Faridovich

Tolstikov Genrikh Aleksandrovich

Dates

2008-11-27Published

2007-04-12Filed