FIELD: medicine; pharmacology.
SUBSTANCE: immunogenic hybrid polypeptide includes mimetic peptide of V-cellular epitope of apolypoprotein B-100 in which C-end of mimetic peptide is merged with N-end of T-helper epitope. Amino acid sequences of polypeptide variants are presented in description. Described is method of specified polypeptide production providing application of host cell transformed with recombinant express vector including gene coding specified polypeptide. Besides, invention concerns vaccine composition including specified immunogenic hybrid polypeptide for obesity prevention or treatment, recombinant express vector and host cell.
EFFECT: excellent anti-obesity activity without induction of immune response or severe by-effects.
15 cl, 25 dwg, 4 tbl, 15 ex
| Title |
Year |
Author |
Number |
| IMMUNOGENIC HYBRID POLYPEPTIDES AGAINST OBESITY AND COMPOSITION OF ANTI-OBESITY VACCINES, CONTAINING SAID POLYPEPTIDES |
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|
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|
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- Pele Chong
- Vejn Tomas
- Jan-Ping Jang
- Shina Lusmore
- Du Juan Charlz Sia
- Majkl Klejn
|
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| MUTANT POLYMERASES OF HEPATITIS B VIRUS |
2012 |
- Marten Perrin
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|
RU2625021C2 |
| POLYEPITOPE PROTEIN COMPOSITION FOR INDUCING IMMUNE RESPONSE AGAINST FOOT-AND-MOUTH DISEASE VIRUS |
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- Andrianova Ekaterina Pavlovna
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|
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2010 |
- Khaitov Rakhim Musaevich
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- Nikolaeva Irina Aleksandrovna
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- Gudima Georgij Olegovich
- Karamov Ehduard Vladimirovich
- Kornilaeva Galina Vladimirovna
- Pavlova Tat'Jana Vladimirovna
- Nekrasov Arkadij Vasil'Evich
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|
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1995 |
- Karpenko L.I.
- Chikaev N.A.
- Melamed N.V.
- Il'Ichev A.A.
- Bajborodin S.I.
|
RU2112039C1 |
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2012 |
- Antonets Denis Viktorovich
- Bazhan Sergej Ivanovich
- Il'Ichev Aleksandr Alekseevich
- Karpenko Larisa Ivanovna
- Borobova Elena Aleksandrovna
- Starostina Ekaterina Vladimirovna
- Smirnova Ol'Ga Jur'Evna
- Oreshkova Svetlana Fedorovna
|
RU2522830C2 |
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2010 |
- Marten Perrin
- Ehnshosp Zhenev'Ev
- Sil'Vestr Natali
- Shmitt Doris
|
RU2555346C2 |
| COMPOUNDS AND METHODS FOR TREATMENT AND DIAGNOSTICS OF CHLAMYDIA INFECTION |
2001 |
- Fling Stiven P.
- Skejki Jasir A.V.
- Probst Peter
- Bkhatija Adzhej
|
RU2410394C2 |
