FIELD: medicine.
SUBSTANCE: injection is carried out, in therapeutically effective dose, of estrogen, or its prodrug, or mixed estrogen/androgen compound, in some cases, combined with estrogen receptor selective modulator (ERSM). As ERSM compounds of similar structure are applied, where: R1 and R2 are chosen from hydrogen, hydroxyl, or radical that in vivo is converted to hydroxyl; Z is none or chosen from -CH2-, -O-, -S-, and -NR3-; R100 is bivalent radical of 4 to 10 intermediate atoms; L is chosen from -SO-, -CON-, -N<, and -SON<; G1 is chosen from hydrogen, C1-C5-hydrocarbon, radical that together with G2 and L forms 5-7-membered heterocyclic ring, and halogen or unsaturated derivatives of previous substitute; G3 is chosen from hydrogen, methyl, and ethyl. In some versions the above treatment is complemented by androgen agents or biphosphonates administering.
EFFECT: effective therapy of diseases mentioned, due to increased action of estrogen receptor selective modulator, combined with lowering estrogen negative action on the organism tissues.
19 cl, 25 dwg, 16 tbl, 12 ex
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Authors
Dates
2008-12-27—Published
2001-01-26—Filed