FIELD: medicine.
SUBSTANCE: skin equivalent is produced that represents extracellular protein matrix, with mesenchymal cells within it and epidermal cells on its surface. As a matrix collagen or fibrin gel is used. As epidermal cells previously selected keratocyte population with stem cell character is used. Application of the invention allows producing skin equivalent, containing cells in active initial growth stage. Skin equivalent is intended for cutaneous cover regeneration in patients with extensive burns, trophic ulcers, bedsores, and other kinds of wound.
EFFECT: prolonged stimulating effect on patient's cells migration and proliferation.
4 cl, 4 ex
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