FIELD: chemistry.
SUBSTANCE: described is method of synthesis of glutei acid derivative, usually monatin, in which 4-protected derivative of hydroxypyroglutei acid is subjected to alkylation with use of alkylating agent, obtaining protected in 4-position derivative of hydroxyl-4-alkylglutei acid, then, obtained derivative is subjected to stages of hydrolysis and protective group removal. Protected in 4-position derivative of hydroxypyroglutei acid can be easily obtained from hydroxyprolin. Said 4-protected derivative of hydroxypyroglutei acid is especially suitable for efficient synthesis of monatin with high optic purity, because reaction of alkylation for this derivative can be carried out selectively in 4-position and stereoselectively, and after alkylation said derivative can be easily converted into derivative of glutei acid.
EFFECT: creation of efficient method of obtaining hydroxypyroglutei acid derivative.
47 cl, 3 ex
