DERIVATIVES OF AROMATIC DICARBOXYLIC ACIDS Russian patent published in 2006 - IPC C07D333/38 A61K31/381 A61P35/00

Abstract RU 2289580 C2

FIELD: organic chemistry, biochemistry, pharmacy.

SUBSTANCE: invention relates to derivatives of aromatic dicarboxylic acids of the general formula (I):

wherein means thiophene ring that can be unsubstituted or substituted with 1 or 2 substitutes; R1 and R2 are similar or different and mean hydrogen atom, branched or unbranched (C₁-C₁₄)-alkyl group that can be unsubstituted or substituted with one or some substitutes, carbocyclic group or heterocyclic group; R1 and R2 form in common with nitrogen atom 3-6-membered cycle, and to their enantiomers, diastereoisomers, racemates and their physiologically acceptable salts. Compounds possess inhibitory effect with respect to activity of histon deacetylase. Also, invention describes a medicinal agent based on compounds of the formula (I).

EFFECT: valuable medicinal and biochemical properties of derivatives.

6 cl, 1 tbl, 18 ex

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RU 2 289 580 C2

Authors

Lezer-Rajff Ul'Rike

Zattel'Kau Tim

Tsimmermann Gerd

Dates

2006-12-20—Published

2002-06-13—Filed