AGONISTS OF RECEPTOR OF PEPTIDE-1, SIMILAR TO GLUCAGONE, THEIR OBTAINING AND APPLICATION Russian patent published in 2008 - IPC C07D263/42 C07D413/12 C07D413/14 A61K31/381 A61K31/421 A61K31/422 A61P3/04 A61P3/10

Abstract RU 2342368 C2

FIELD: chemistry, pharmacology.

SUBSTANCE: claimed invention relates to agonist of receptor of glucagone-like peptide-1, which can be applied for treatment of diseases, caused by disturbance of glycometabolism, such as type II diabetes, insensibility to insulin or obesity. In structural formula each of Ar₁ and Ar₂ independently represents substituted phenyl, and group-substituents represent one, two or three groups selected from C₁-C₆alkoxyl, C₁-C₆-alkanoylamino, which is substituted with hydroxyl (which contains groups-substituents, including hydroxyl); C₃-C₆-cyclolkanoylamino, C₂-C₆-lkenoylamino; banzoylamino, banzyloxy C₁-C₆-alkanoylamino, thenoyloxy, tret-butoxyformamido, adamantanformamido; and mandeloylamino; X represents O; Y represents O. Invention also relates to method of obtaining agonist, and to its application for obtaining medication for treatment of diseases caused by disturbance of glycometabolism.

EFFECT: obtaining medication for treatment of diseases caused by disturbance of glycometabolism.

8 cl, 4 ex, 2 tbl, 2 dwg

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RU 2 342 368 C2

Authors

Nan' Fadzhun'

Van Mingvej

Van Ven'Lon

Shou Kajkhon

Dates

2008-12-27—Published

2003-12-25—Filed