SECONDARY AMINES AS RENIN INHIBITORS Russian patent published in 2011 - IPC C07D211/70 C07D211/34 C07D401/14 C07D413/10 C07D413/14 C07D451/02 C07D471/08 A61K31/439 A61K31/4418 A61P9/00 A61P13/12 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula

, where the dotted line in the 6-member nitrogen-containing ring Z of formula (I) (said ring Z consists of ring atoms numbered 1 to 6) indicates that a double bond is either present in the 3,4-position of the ring Z of formula (I), or a double bond is absent in ring Z of formula (I); and where the double bond may be present in the 3,4-position of the ring Z of formula (I); or: the double may be absent in ring Z of formula (I) if: i) X denotes N or N⁺-O^-, or ii) V denotes -O-CH₂-Q-, or iii) W denotes para-substituted phenyl or para-substituted pyridinyl, and V denotes pyrrolidinyl of formula:

X denotes CH, N, or N⁺-O^-; W denotes para-substituted phenyl or para-substituted pyridinyl; V denotes -O-CH₂-Q-, where Q is bonded with a group U of formula (I), or V denotes pyrrolidinyl of formula:

U denotes mono-, di-, tri- or tetra-substituted aryl, where the substitutes are independently selected from C_1-7-alkyl and halogen; Q denotes a five-member heteroaryl with two or three heteroatoms independently selected from O and N; R¹ denotes C_1-7-alkyl or cycloalky; R² denotes halogen or C_1-7-alkyl; R³ denotes halogen or hydrogen; R⁴ denotes C_1-7-alkyl-O-(CH₂)_0-4-CH₂-; R'R"N-(CH₂)_0-4-CH₂-, where R' and R" are independently selected from a group consisting of hydrogen, C_1-7-alkyl (optionally substituted with one-three fluorine atoms), cyclopropyl (optionally substituted with one-three fluorine atoms), cyclopropyl- C_1-7-alkyl (optionally substituted with one-three fluorine atoms) and -C(=O)-R"', where R'" denotes C_1-4-alkyl, C_1-4-alkoxy, -CH₂-CF₃, or cyclopropyl; or R¹²NH-C(=O)·(O)_0-1-(CH₂)_0-4-, where R¹² denotes C_1-4-alkyl or cyclopropyl; and n equals 0; and salts thereof. The invention also relates to a pharmaceutical composition.

EFFECT: obtaining novel biologically active compounds having inhibiting effect on renin.

21 cl, 112 ex