CFTR REGULATORS AND METHODS OF USING Russian patent published in 2020 - IPC C07D241/44 C07D401/06 C07D403/06 C07D405/06 A61K31/498 A61P1/10 A61P27/02 

FIELD: pharmaceuticals.

SUBSTANCE: invention refers to a compound of formula I:

(I)

or its pharmaceutically acceptable salt, where: L¹ is -CH₂-; R²⁰ is , unsubstituted pyridyl, unsubstituted furanyl or unsubstituted thiophenyl; or L¹-R²⁰ is ; R¹ and R⁴ are hydrogen; R² denotes hydrogen or halogen; R³ is -NO₂, -CN or halogen; R⁵ denotes hydrogen, -NO₂ or -NH₂; or R² and R³ are bonded to form, together with atoms, to which they are attached, , R⁶ is hydrogen or halogen; R⁷ is hydrogen; R⁸ denotes hydrogen or halogen; R⁹ denotes hydrogen, -CH₃ or halogen; R¹⁰ and R¹¹ are hydrogen or halogen and R¹², R¹³ and R¹⁴ are hydrogen, which activate CFTR.

EFFECT: as a result, CFTR regulators and methods of their application are proposed.

41 cl, 25 dwg, 6 tbl, 6 ex