METHOD OF AMINE SPLIT EFFECTIVE FOR TREATMENT OF DISORDERS ASSOCIATED WITH INSULIN RESISTANCE SYNDROME Russian patent published in 2009 - IPC C07D251/10 

Abstract RU 2344131 C2

FIELD: chemistry.

SUBSTANCE: describes method of splitting racemic compounds of formula (I) stated below: where R1, R2, R3 and R4 independently mean H or C1-6alkyl; R6 - C1-6alkyl or C3-8cycloalkyl by reaction, racemic compounds I with chiral acid, that is: (-)-di-O,O'-n-tolyl-L-tartaric, R(-)-or S(+)-1,1'-binaphthalene-2,2'-diyl hydrophosphate with following purification of derived diastereoisomer salts and release of required enantiomer of formula (I) in the form of pharmaceutically acceptable salt.

EFFECT: easy and efficient production of pure enantiomers.

10 cl, 2 ex, 4 dwg

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RU 2 344 131 C2

Authors

Muane Zherar

Kravo Dan'El'

Passemar T'Erri

Dates

2009-01-20Published

2004-04-06Filed