1,1,2,2-TETRA (HETERO) ARYLETHANES OR 1,1,2-TRI (HETERO) ARYL-2-HETEROCYCLYLETHANES AS POTASSIUM CHANNEL INHIBITORS Russian patent published in 2009 - IPC C07D401/14 A61K31/444 A61P9/06

Abstract RU 2344134 C2

FIELD: chemistry.

SUBSTANCE: this invention refers to compounds chosen from group including (R)-N-{6-[1-(4-fluorophenyl)-2,2-dipyridine-3-ylethyl]pyridine-2-yl}methane sulphonamide, (S)-N -{6-[1-(4- fluorophenyl])-2,2-dipyridine-3-ylethyl] pyridine-2-yl}methane sulphonamide, (R)-N-{6-[1-(3-cyanophenyl)-2,2-dipyridine-3-ylethyl]pyridine-2-yl}methane sulphonamide, (S)-N-{6-[1-(3-cyanophenyl)-2,2-dipyridine-3-ylethyl]pyridine-2-yl}methane sulphonamide, (R)-N-{6-[1-(6-methoxypyridine-6-yl)-2,2-dipyridine-3-ylethyl]pyridine-2-yl}methane sulphonamide, (S)-N-6-[1-(6-methoxypyridine-6-yl)-2,2-dipyridine-3-ylethyl]pyridine-2-yl}methane sulphonamide, (R)-3-[1-(2-aminopyrimidine-2-yl)-2,2-dipyridine-3-ylethyl]benzonitrile and (S)-3-[1-(2-aminopyrimidine-2-yl)-2,2-dipyridine-3-ylethyl]benzonitrile, as well as to method of mammal treatment performed or facilitated with K_v1.5 inhibition, to pharmaceutical preparation with K_v1.5 inhibiting action and to pharmaceutical composition with K_v1.5 inhibiting action.

EFFECT: production of new compounds which can be applied as potassium channel inhibitors for heart arrhythmia treatment.

6 cl, 5 ex

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RU 2 344 134 C2

Authors

Bilodo Mark T.

U. Chzhitsaj

Khartnett Dzhon

Dates

2009-01-20—Published

2005-07-25—Filed