1,3,4-OXADIAZOLE SULPHONAMIDE DERIVATIVES AS HISTONE DEACETYLASE INHIBITORS 6 AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF Russian patent published in 2019 - IPC C07D271/10 C07D413/00 A61K31/4245 A61P1/00 A61P3/00 A61P9/00 A61P17/00 A61P19/00 A61P25/00 

Abstract RU 2697665 C1

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of formula I, their stereoisomers or their pharmaceutically acceptable salts, to their use for preparing therapeutic agents, to pharmaceutical compositions containing them, and to a method for treating HDAC6-mediated diseases. Formula I

.

EFFECT: technical result is obtaining novel compounds having histone 6 (HDAC6) deacetylase inhibition activity, which are effective for preventing or treating HDAC6 mediated diseases.

10 cl, 2 tbl, 339 ex

Similar patents RU2697665C1

Title Year Author Number
1,3,4-OXADIAZOLE SULPHAMIDE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 2016
  • Lee, Jaekwang
  • Han, Younghue
  • Kim, Yuntae
  • Min, Jaeki
  • Bae, Miseon
  • Kim, Dohoon
  • Jin, Seokmin
  • Kyung, Jangbeen
RU2695227C1
1,3,4-OXADISOLAMIDE DERIVATIVE COMPOUND AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 2016
  • Lee, Jaekwang
  • Ko, Moo Sung
  • Han, Younghue
  • Kim, Yuntae
RU2700696C2
1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 2021
  • Li, Chang Kon
  • Ko, Mu Sung
  • Gvak, Dal-Jong
  • Yun, Sek Khyan
  • Li, Se Yang
  • Kim, Khyuntszin Majkl
RU2822180C1
OXADIAZOLAMINE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 2016
  • Kim, Yuntae
  • Lee, Chang Sik
  • Oh, Jung Taek
  • Song, Hyeseung
  • Choi, Jin
  • Lee, Jaeyoung
RU2695133C1
1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 2021
  • Li, Chan Kon
  • Ko, Mu Sun
  • Yun, Sok Khen
  • Kim, Khendzhin Majkl
RU2810081C1
1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEM 2019
  • Lee, Chang Sik
  • Oh, Jung Taek
  • Yun, Hokeun
  • Song, Hyeseung
  • Kim, Hyunjin Michael
RU2763936C1
NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 2021
  • Lee, Jae Kwang
  • Min, Jaeki
  • In, Jin Kyung
  • Kim, Yi Hyun
  • Jeon, Bomi
  • Han, Younghue
  • Yoon, Hong Ju
  • Kim, Hyunjin Michael
RU2817736C1
NOVEL DERIVATIVE OF PURINYLPYRIDINYLAMINO-2,4-DIFLUOROPHENYLSULPHONAMIDE, ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF ITS OBTAINING AND PHARMACEUTICAL COMPOSITION, WHICH HAS INHIBITION ACTIVITY WITH RESPECT TO RAF-KINASE, CONTAINING CLAIMED COMPOUND AS ACTIVE INGREDIENT 2011
  • Shim Eun Kiong
  • Kim Nam Doo
  • Shim Tae Bo
  • Kim Seung Jong
RU2550038C2
1,3,4-OXADIAZOLE HOMOPHTHALIMIDE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 2020
  • Lee, Chang Sik
  • Oh, Jung Taek
  • Yun, Hokeun
  • Song, Hyeseung
  • Kim, Hyunjin Michael
RU2793331C1
1,3,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITOR AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF 2021
  • Li, Chang Kon
  • Ko, Mu Sung
  • Yun, Sek Khyan
  • Li, Se Yang
  • Kim, Khyuntszin Majkl
RU2822624C1

RU 2 697 665 C1

Authors

Lee, Jaekwang

Han, Younghue

Kim, Yuntae

Choi, Daekyu

Min, Jaeki

Bae, Miseon

Yang, Hyunmo

Kim, Dohoon

Dates

2019-08-16Published

2016-07-27Filed