(R)-ARYLALKYLAMINO DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2012 - IPC C07C309/65 C07C311/03 C07C233/01 C07C233/64 C07D213/82 C07D307/68 C07D211/34 C07D207/06 C07D277/42 A61K31/18 A61K31/165 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to certain (R)-arylalkylamino derivatives of formula , wherein R is specified in the following values: - 2-thiazolyl substituted by a trifluoromethyl group; -COR_a, SO₂R_a, wherein R_a is specified in the following values -C₁-C₅-alkyl, C₃-C₆- cycloalkyl, phenyl, a heteroaryl group specified in thiophen, furan and pyridine with heteroaryl being unsubstituted or substituted by a group specified in COOH and C₁-C₄-acyloxy; - ω-aminoalkylamino group of formula , wherein X represents: - linear or branched C₁-C₆ alkylene; R2 and R3 together with N atom bound therewith form a 3-7-member nitrogen-containing heterocyclic ring of formula , wherein Y represents a single bond; and p is equal to 0 or represents an integer 1 to 3; R1 represents linear or branched C₁-C₅ alkyl; Ar represents a phenyl group substituted by one or more groups independently specified in benzoyl, heteroarylcarbonyl wherein the heteroaryl group represents furan, 4'-trifluoromethane sulphonyloxy-, 4'-[1-methyl-1-(phenylsulphonyl)ethyl]- and 4'-benzole sulphonyloxy-. The compounds under the invention provides unexpectedly strong inhibiting action on C5a-induced chemotaxis of human PMN.

EFFECT: preparing (R)-arylalkylamino derivatives applicable in treating the pathologies dependent from chemotaxic activity of neutrophils and monocytes induced by the C5a complement fraction.

6 cl, 1 tbl, 10 ex