FIELD: chemistry.
SUBSTANCE: present invention pertains to the amorphous form of the 42-ester of rapamycin and 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid. The invention also relates to methods of obtaining the amorphous form and to pharmaceutical compositions containing this amorphous form and having immunosuppressive, anti rejection, antifungal, antiphlogistic and antiproliferative activity.
EFFECT: increased solubility and bioavailability.
24 cl, 7 dwg, 6 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| POLYMORPHOUS AND AMORPHOUS FORMS OF {2-FLUORINE-5-[3-((E)-2-PYRIDINE-2-ILVINYL)-1N-INDAZOLE-6-ILAMINE]PHENYL}AMIDE 2, 5-DIMETHYL-2N-PYRAZOLE-3-CARBONIC ACID | 2005 |
|
RU2324692C1 |
| IMPROVED CRYSTALLINE MATERIAL | 2007 |
|
RU2444513C2 |
| (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID | 2016 |
|
RU2726623C2 |
| CRYSTALLINE FORMS OF 3-[5-(2-FLUOROPHENYL)-[1,2,4]OXADIAZOL-3-YL]BENZOIC ACID, AND USE THEREOF AND METHODS FOR PREPARING | 2007 |
|
RU2474577C2 |
| REGIOSPECIFIC SYNTHESIS OF RAPAMYCIN 42-ESTER DERIVATIVES | 2005 |
|
RU2387657C2 |
| POLYMORPHOUS FORM OF LERCANIDIPINE HYDROCHLORIDE AND SYNTHESIS METHOD THEREOF | 2006 |
|
RU2425033C2 |
| ORAL COMPOSITIONS | 2003 |
|
RU2326654C2 |
| METHOD OF PRODUCING IVABRADINE HYDROCHLORIDE AND POLYMORPHS THEREOF | 2008 |
|
RU2473544C2 |
| CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDINE-2-YL)AZETIDINE-1-YL]METHANONE | 2016 |
|
RU2762181C2 |
| SALTS AND POLYMORPHS OF SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE | 2015 |
|
RU2732125C2 |
