FIELD: chemistry.
SUBSTANCE: present invention pertains to the amorphous form of the 42-ester of rapamycin and 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid. The invention also relates to methods of obtaining the amorphous form and to pharmaceutical compositions containing this amorphous form and having immunosuppressive, anti rejection, antifungal, antiphlogistic and antiproliferative activity.
EFFECT: increased solubility and bioavailability.
24 cl, 7 dwg, 6 tbl, 7 ex
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Authors
Dates
2009-02-10—Published
2004-08-16—Filed