MIXTURES OF OLIGOSACCHARIDES, WHICH ARE DERIVATIVES OF HEPARIN, METHOD OF OBTAINING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Russian patent published in 2009 - IPC C08B37/10 A61K31/727 A61K31/715 A61P7/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: mixtures of oligosaccharides with antithrombotic activity, with general structure of constitutive polysaccharides of heparin, have the following characteristics: average molecular weight from 1800 to 2400 Daltons, anti-Xa activity, from 190 M.units./mg to 450 M.units/mg, anti-IIa activity equals zero or practically equal to zero. Constitutive oligosaccharides of these mixtures: contain 2-16 saccharide links, have a 2-0-sulphate-4,5-unsaturated uronic acid link on one of their ends. The mixtures contain from 30 to 60% hexasaccharide fraction, and the hexasaccharide fraction contains from 20 to 70% hexasaccharide with the following formula: in form of a salt of alkali or alkali-earth metal. A method is given of obtaining oligosaccharide mixtures and antithrombotic pharmaceutical compositions containing them, as well as a method of determining activity of oligosaccharide mixtures.

EFFECT: obtaining oligosaccharides with antithrombotic activity.

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