DERIVATIVES OF POLYSACCHARIDES WITH HIGH THROMOBITIC ACTIVITY IN PLASMA Russian patent published in 2009 - IPC C08B37/10 A61K31/715 A61K31/727 A61P7/02 

FIELD: chemistry.

SUBSTANCE: method of producing sulphated glycosaminoglycans from N-acetylheparosan involves a) N-deacetylation and N-sulphation of polysaccharide of N-acetylheparosan, obtained from natural or recombinant bacterial strains, preferably E. coli K5, b) enzymic epimerisation using glucoronyl-C5-epimerase, c) partial O-sulphation with subsequent partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate stage of controlled depolymerisation, characterised by the fact that, both O-sulphations (O-sulphation and 6-O-sulphation) are partial. The invention also relates to products obtained in accordance with the method, which exhibit ratio between anti-Xa and anti-IIa-activity equal to 1 or greater than 1, and to antithrombotic and anticoagulant pharmaceutical compositions, containing the said products combined with suitable and pharmaceutically acceptable fillers and/or solvents.

EFFECT: increased effectiveness of composition and method of treatment.

61 cl, 18 dwg, 6 tbl, 18 ex