FIELD: pharmacy.
SUBSTANCE: group of inventions relates to a method for calcium nadroparin preparation, wherein heparin is dissolved in water, sodium nitrite is added and pH is adjusted to 2-3 by treatment with hydrochloric acid, the solution is kept until nitrite disappearance, and pH is then adjusted to 9-11 by hydroxide sodium addition and then sodium borohydride is introduced into the solution. The group of inventions also relates to calcium nadroparin, obtained by this method, calcium nadroparin application for treatment of diseases requiring anticoagulation. The group of inventions provides a quantity of the low molecular weight fraction (below 2000 Da) of max. 15% of the total fraction 2000-8000 Da and less than 2000 Da.
EFFECT: method cost reduction.
5 cl, 5 ex, 1 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR OBTAINING NADROPARIN CALCIUM | 2020 |
|
RU2753678C1 |
| AGENT WITH ANTICOAGULATING EFFECT AND ITS APPLICATION METHOD | 2021 |
|
RU2799028C2 |
| PURIFIED HEPARIN FRACTION, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION CONTAINING ON SAID | 1994 |
|
RU2133253C1 |
| IMPROVED METHOD FOR PRODUCTION OF DALTEPARIN SODIUM | 2019 |
|
RU2783697C2 |
| EPIMERISED K5 POLYSACCHARIDE DERIVATIVES WITH HIGH SULFATION DEGREE | 2003 |
|
RU2333222C2 |
| METHOD OF PRODUCING PROPOFOL ACTIVE PHARMACEUTICAL SUBSTANCE | 2022 |
|
RU2822829C2 |
| METHOD OF OBTAINING BIOLOGICALLY ACTIVE MUCOPOLYSACCHARIDES | 0 |
|
SU1531859A3 |
| METHOD OF OBTAINING LOW-MOLECULAR HEPARIN | 2012 |
|
RU2512768C1 |
| METHOD OF OBTAINING THE PHARMACEUTICAL SUBSTANCE BASED ON IOPROMIDE | 2017 |
|
RU2655693C1 |
| NON-ANTICOAGULANT GLYCOSAMINOGLYCANS WITH REPEATING DISACCHARIDE UNITS, AND THEIR MEDICAL APPLICATION | 2012 |
|
RU2617764C2 |
