DERIVATIVES OF N-HETEROCYCLYLMETHYLMENZAMIDES, OBTAINMENT AND APPLICATION IN THERAPY Russian patent published in 2009 - IPC C07D471/08 C07D487/08 A61K31/4748 A61P25/00

Abstract RU 2346945 C2

FIELD: chemistry.

SUBSTANCE: invention claims compound of the general formula (I) , where R is hydrogen atom or vinyl group; n is 1, X is a group of the formula CH or nitrogen atom, R₁ is either phenyl or naphthyl group, or cyclohexyl group, or heteroaryl group, R₂ is either hydrogen atom or one or more substitutes selected out of halogen atoms and trifluoromethyl, alkyl, alkoxyl phenyloxy, hydroxyl groups or group of the general formula -NR₄R₅, SO₂NR₄R₅, or group of the formula -OCF₂O-, each of R₄ and R₅groups is hydrogen atom or alkyl group; and method of obtaining compound of the general formula (I), medicine, pharmaceutical composition. Compounds display special effect as specific inhibitors of glycine GlyT1 and/or GlyT2 transmitters and thus are applied in treatment of various diseases.

EFFECT: obtaining compounds with high specific inhibition effect.

13 cl, 2 tbl, 5 ex

Similar patents RU2346945C2

Title	Year	Author	Number
DERIVATIVES OF N-[PHENYL(PYRROLIDIN-2-YL)METHYL]BENZAMIDE AND N-[(AZEPAN-2-YL)PHENYLMETHYL]BENZAMIDE, METHOD OF OBTAINING SAID COMPOUNDS AND USE THEREOF IN THERAPY	2004	Dargazanli Zhiad Ehstenn-Butu Zhenev'Ev Medesko Florans Rakotoarisoa Natali	RU2386614C2
N-PHENYL(PIPERIDINE-2-YL)METHYL-BENZAMIDE DERIVATIVES, AND THEIR APPLICATION IN THERAPY	2004	Dargazanli Zhiad Ehstenn-Butu Zhenev'Ev Maga Paskal'	RU2351588C2
SUBSTITUTED BENZIMIDAZOLE COMPOUNDS, METHODS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIVIRAL EFFECT BASED ON THEREOF	1993	Leroj B.Taunsend Dzhon Charl'Z Drehch Stiven Spenser Gud S'Juzn Mehri Del'Judzh Majkl Tolar Martin	RU2141952C1
N-[PHENYL(ALKYLPIPERIDINE-2-YL]BENZAMIDE DERIVATIVES, AND THEIR APPLICATION IN THERAPY	2004	Dargazanli Zhiad Ehstenn-Butu Zhenev'Ev Veronik Korinn	RU2351589C2
PRODRUG OF THE AMINO ACID DERIVATIVE	2017	Otake, Norikazu Hashihayata, Takashi Matsuda, Yohei Masuda, Seiji Yamauchi, Yuko	RU2739318C2
SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA-AMYLOID SECRETION	2003	Kreft Ehntoni Frehnk Koul Derek Sesil Uoller Kevin Rodzher Stok Dzhozef Rehjmond Katterer Kristina Marta Kubrak Dennis Majkl Mann Charl'Z Uil'Jam Mur Uil'Jam Dzhej Kejsbir Dehvid Skott	RU2321394C2
CONDENSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE	2007	Takakhasi Khisasi Komorija Satosi Kitamura Takakhiro Odagiri Takasi Inagaki Khiroaki Tsuda Tosifumi Nakajama Kijosi Takemura Makoto Josida Keniti Mijauti Rie Nagamoti Masatosi	RU2443698C2
BENZIMIDAZOLE DERIVATIVES USEFUL AS T/L CHANNEL BLOCKERS	2009	Juble Fransis Khil'Pert Kurt Renneberg Dorte	RU2478095C2
AMIDE DERIVATIVES OF PYROSOL	2015	Bek Khilari Plejk Buker Shon Kejt Bregman Govard Ki Viktor Dzh. Chakka Nagashri Kashing Timoti D. Epstejn Oleg Foks Brajan M. Gens-Mejer Stefani Khao Syaolin Khibiya Kenta Khirata Dzyun Khua Chzhikhao Khyuman Dzhejson Kakuda Sindzi Lopez Patrisiya Nakadzima Reta Okada Kadzukhisa Olson Stiven Kh. Oono Khiroyuki Pennington Lyuis D. Sasaki Kosuke Simada Kejko Sin Yunsok Uajt Rajan D. Vurts Rajan P. I Syuyan Chzhen Syao Mej	RU2658827C2
CONDENSED TRICYCLIC BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Kalmiano Mark Daniel Defejs Sabine Dyure Veronik Delini Mikhael Kher Yag Paul Dzhekson Viktoriya Elizabet Keje Zhan Kroplin Boris Mak-Koss Malkolm Sabnis Jogesh Anil Selbi Mattyu Dankan Svinnen Dominik Lui Leon Van-Khautvin Natali Chzhu Chzhaonin Vener Folkmar Khajnelt Uve	RU2689777C1

RU 2 346 945 C2

Authors

Dargazanli Zhiad

Ehstenn-Butu Zhenev'Ev

Maga Paskal'

Marabu Benua

Rozher P'Er

Dates

2009-02-20—Published

2004-10-15—Filed