FIELD: chemistry.
SUBSTANCE: invention relates to novel compounds of general formula (I): 
where: n equals 1 or 3; R1 denotes H, straight or branched (C1-C7)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl; X denotes H, either one or more substitutes selected from halogen atoms and the following groups: CF3, straight or branched (C1-C6)alkyl, (C1-C6)alkoxy; R2 denotes H, one or more substitutes selected from halogen atoms, CF3, straight or branched (C1-C6)alkyls, (C1-C6)alkoxy, -NR3R4, -SO2NR3R4, -CONR3R4, where R3 and R4 each independently denotes H, straight or branched (C1-C6)alkyl, in form of a base or additive salt with an acid.
EFFECT: formula I compounds are inhibitors of glycine glyt 1 and/or glyt 2 carriers, which enables their use in preparing a pharmaceutical composition and a medicinal agent.
1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-[PHENYL(ALKYLPIPERIDINE-2-YL]BENZAMIDE DERIVATIVES, AND THEIR APPLICATION IN THERAPY | 2004 |
|
RU2351589C2 |
| N-[HETEROARYL(PIPERIDINE-2-YL)METHYL]BENZAMIDE DERIVATIVES AND APPLICATION IN THERAPY | 2004 |
|
RU2351596C2 |
| N-PHENYL(PIPERIDINE-2-YL)METHYL-BENZAMIDE DERIVATIVES, AND THEIR APPLICATION IN THERAPY | 2004 |
|
RU2351588C2 |
| DERIVATIVES OF N-HETEROCYCLYLMETHYLMENZAMIDES, OBTAINMENT AND APPLICATION IN THERAPY | 2004 |
|
RU2346945C2 |
| DERIVATIVES OF 6-AMINO QUINAZOLINE OR 3-CYANOQUINOLINE, METHODS OF THEIR PRODUCTION AND THEIR APPLICATION AS INHIBITORS OF RECEPTOR TYROZINE KINASES EGFR OR HER-2 | 2010 |
|
RU2536102C2 |
| PROTEOLYSIS MODULATORS AND RELATED USES | 2019 |
|
RU2805511C2 |
| CYCLOPROPYLAMIDE DERIVATIVES AS N-HISTAMINE RECEPTOR MODULATORS | 2007 |
|
RU2449989C2 |
| FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS AND USE THEREOF | 2017 |
|
RU2732127C1 |
| INHIBITORS OF HEPATITIS C VIRUS HAVING RODLIKE CHAIN AND COMPRISING {2-[4-(BIPHENYL-4-YL)-1H-IMIDAZO-2-YL]PYRROLIDIN-1-CARBONYLMETHYL}AMINE FRAGMENT | 2012 |
|
RU2625787C2 |
| LIGAND CONJUGATE WITH CYTOTOXIC DRUG PREPARATION, METHOD AND APPLICATION THEREOF | 2016 |
|
RU2708461C2 |
