MICROFLUIDISED OIL-IN-WATER EMULSIONS AND VACCINE COMPOSITIONS Russian patent published in 2009 - IPC A61K39/39 A61P31/00 

Abstract RU 2347586 C2

FIELD: medicine; biotechnologies.

SUBSTANCE: vaccine composition contains saponin glycoside, sterol and antigen, where specified saponin glycoside and specified sterol are associated with each other to create complexes in the form of helical micelles. Specified antigen is mixed with specified helical micelles, but is not included into their composition. Vaccine contains saponin glycoside and sterol with the weight proportion of saponin to sterol - from 1:100 to 5:1. Specified saponin glycoside and specified sterol are associated with each other to create complexes in the form of helical micelles with immunopotentiating activity. Vaccine additionally contains immunologically efficient amount of antigen. Specified antigen is mixed with specified helical micelles, but is not included into their composition. Adjuvant oil-in-water composition contains Quil A and cholesterol with weight proportion of saponin and sterol from 1:100 to 5:1 in carrier acceptable for veterinary medicine. Specified Quil A and cholesterol are associated with each other to create complexes in the form of helical micelles with immunopotentiating activity, where oil used is non-metabolised oil. Besides specified helical micelles are microfluidized with carrier acceptable for veterinary science to produce submicron oil-in-water emulsion. Method of vaccine production according to clause 1, comprising the following stages: a) preparation of antigen composition in buffer; b) addition of saponin to composition from stage a); and c) addition of sterol in alcohol to composition from stage b). This invention is related to submicron oil-in-water emulsions, which are acceptable as vaccine adjuvant. Besides the present invention is related to vaccine compositions that contain antigen combined directly in composition of such vaccine or separately.

EFFECT: higher immunogenicity of antigens.

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RU 2 347 586 C2

Authors

Dominovski Pol Dzhozef

Klouz Pamela Kej

Krebs Richard Li

Mannan Ramasami Mannar

Dates

2009-02-27Published

2005-03-24Filed