FIELD: medicine, pharmaceutics.
SUBSTANCE: invention concerns a vaccine for preventing an infection caused by at least one of Leptospira, bovine herpes virus, parainfluenza virus and bovine respiratory syncytial virus. The presented vaccine contains heated bacterin Leptospira having the lipase activity of 50% or less as compared to the pre-heating lipase activity of bacterin and maintaining the antigenic activity, and 1-3 live viruses specified in a group consisting of bovine herpes virus, parainfluenza virus and bovine respiratory syncytial virus. The above heating involves Leptospira bacterin heating to temperature 60°C to 70°C for the period of time from 5 to 10 hours.
EFFECT: invention enables producing the stable vaccines maintaining the virus infectivity.
7 cl, 5 ex
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Authors
Dates
2015-11-27—Published
2011-04-20—Filed