ANTIBODIES BISPECIFIC TO ERB-B AND THEIR APPLICATION IN TUMOUR TREATMENT Russian patent published in 2009 - IPC A61K38/36 A61K39/395 C07K16/18 C07K16/28 C07K16/32

Abstract RU 2349340 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns medicine, particularly immunotherapy. Invention claims bispecific antibody and its application in tumour treatment. New antibody can link to EGF receptor and includes two antigene-binding sites linking to different epitopes of indicated receptor, thus ensuring higher receptor engagement by antibodies at the same dosage. It allows for higher antibody density on receptor and significant inhibition of tumour growth and/or enhancement of solid tumour or metastasis apoptosis.

EFFECT: higher receptor engagement by antibodies at the same dosage.

16 cl, 2 ex

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RU 2 349 340 C2

Authors

Krejsh Khans-Georg

Dates

2009-03-20—Published

2003-10-09—Filed