5-SUBSTITUTED DERIVATIVES OF 1,1-DIOXO-1,2,5-THIAZOLIDIN-3-ONE AS PTPase 1B INHIBITORS Russian patent published in 2009 - IPC C07D285/10 C07D417/06 A61K31/433 A61P3/10 

Abstract RU 2349589 C2

FIELD: chemistry.

SUBSTANCE: present invention pertains to mew compounds with formula (I), their pharmaceutical salts and ester derivatives. In general formula (I) n equals 0 or an integer from 1 to 4; Z is -(CHR8)m-, -(CH2)mO(CHR8)r-, -(CH2)mS(CHR8)r- or -(CH2)mNR9(CHR8)r-, L3 is -(CHR)S-, where R is represents hydrogen and s equals 1, Q2 is oxygen, X and Y independently represent CH or nitrogen; or -X=Y- represents sulphur, oxygen. Description of the rest of the radicals is given in the summary of invention.

EFFECT: invented compounds have inhibiting effects on PTPase.

12 cl, 3 dwg, 51 ex

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RU 2 349 589 C2

Authors

Koppola Gehri Mark

Dejvis Dzhon Uill'Jam

Dzhevell Charlz Fransis Dzhr.

Li Juchin'

Uehring Dzhejms Richard

Sperbek Donald Mark

Stams Travis Mat'Ju

Topiol Sidni Uolf

Vlattas Isidoros

Dates

2009-03-20Published

2003-04-02Filed