FIELD: medicine.
SUBSTANCE: what is presented is the use of an ileal bile acid transporter (IBAT) inhibitor representing some benzothiazepine derivatives for preparing a drug for the use in treating and/or preventing constipation in a warm-blooded animal and human. The invention consists in ileal bile acid transportation wherein the bile acids are used as endogenous relaxants.
EFFECT: it is shown that the IBAT administration increases a fecal matter amount after the animals kept the low-fibre and high-protein diet or in a model of constipation either caused by morphine hydrochloride, or following typhlectomy.
4 cl
| Title |
Year |
Author |
Number |
| IBAT ANTIOXIDANT APPLICATION FOR TREATMENT OR PREVENTION OF COPROSTASIA |
2004 |
- Abrakhamsson Khasse Roland
- Gillberg Per-Goran
|
RU2342928C2 |
| IBAT INHIBITOR FOR TREATING HEPATIC DISORDERS |
2011 |
- Jillberg Per-Jeran
- Graffner Khans
- Starke Ingemar
|
RU2591188C2 |
| BENZOTHIADIAZEPINE DERIVATIVES AND METHOD FOR PRODUCTION THEREOF (VARIANTS) |
2002 |
- Starke Ingemar
- Dal'Strum Mikaehl' Ul'F Jukhan
- Blumberg David
- Alenfal'K Suzanne
- Sharet Ture
- Lemurell' Malin
|
RU2305681C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTORS ACTIVATED BY PEROXISOME PROLIFERATOR (PPARα), METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR TREATMENT OF DYSLIPIDEMIA IN DIABETES MELLITUS TYPE 2 |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2303031C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTOR (PPARα) ACTIVATED BY PEROXISOME PROLIFERATORS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR DYSLIPIDEMIA TREATMENT AND TYPE 2 DIABETES MELLITUS |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2300517C2 |
| PHARMACEUTICAL COMBINATION COMPRISING IBAT-INHIBITOR AND BILE ACID BINDER |
2011 |
- Jillberg Per-Jeran
- Graffner Khans
- Starke Ingemar
|
RU2619215C2 |
| BENZOTHIADIAZEPINE DERIVATIVES, METHOD OF THEIR OBTAINING AND APPLICATION, PHARMACEUTICAL COMPOSITION WITH INHIBITION EFFECT ON ILEUM BILE ACID TRANSFER |
2003 |
- Ingemar Starke
- Mikaehl' Ul'F Jokhan Dal'Strum
- Mats Peter Nordberg
- Sjuzanna Alenfal'K
- Andreas Krister Vall'Berg
- Stig Jonas Bostrum
|
RU2333205C2 |
| 1,5-BENZOTHIAZEPINES AND EMPLOYMENT THEREOF AS ANTIHYPERLIPIDEMIC DRUGS |
2001 |
- Starke Ingemar
- Dal'Strom Mikaehl'
- Blomberg David
|
RU2302414C2 |
| DERIVATIVES OF PEPTIDES COMPRISING THIAZEPINE GROUP FOR TREATMENT OF HYPERGLYCEMIC STATES |
2003 |
- Starke Ingemar
- Dal'Strom Mikaehl' Ul'F Jokhan
- Alenfal'K Susanna
- Sk'Jaret Ture
- Lemurell' Malin
|
RU2315772C2 |
| ORTHO-SUBSTITUTED DERIVATIVES OF BENZOIC ACID, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING |
2003 |
|
RU2288912C2 |
