DOUBLE ESTERS Russian patent published in 2009 - IPC C07C69/50 C07C69/48 C07C69/46 C07C69/44 C07C69/34 A61K31/225 A61K31/23 

FIELD: chemistry.

SUBSTANCE: in formula n represents an integer 4 to 12, preferentially 6, 7 or 8, most preferentially 7; R¹ represents hydrogen, C_1-15-alkyl group or, preferentially group -CHR³-O-CO-R²; each R² independently represents C_1-15alkyl or alkoxy-group or aryl group with up to 16 carbon atoms, and each R³ independently represents hydrogen or C_1-15-alkyl group, or to their physiologically acceptable salts, without bis(1-(acetyloxy)ethyl)nonanedioate. Besides, invention concerns method of these compounds production, to pharmaceutical composition for treating acne, acne rosacea, hyperpigmentation, wound healing, senile keratosis, basal cell carcinoma or bacterial infection or treating or preventing cancer based thereon, to method for treating the specified conditions, as well as to application of compounds of formula I as pharmaceutical substance of acyloxymethyl ester n-alkan-α,ω-dicarboxylic acid or its salt or ester to produce a medicine for treating human condition sensitive to treatment with specified pharmaceutical substance of dicarboxylic acid.

EFFECT: higher efficiency of composition and methods of treatment.

8 cl, 17 ex