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2 257 388

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Application

2002103384/04, 2000-06-23

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Start date

2000-06-23

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Actual filing date

2000-06-23

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Published

2005-07-27

(72)

Inventor

Dodd Dzhon G.Genri Dzhejms R.Rupert Kennet K.Bullington Dzhejms L.Kholl Dehniel A.

(73)

Holder

Orto-Maknejl Farmas'Jutikal, Ink.

OXATHIEPINO[6,5-B]DIHYDROPYRIDINES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2005 - IPC

Abstract RU 2257388 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new oxathiepino[6,5-b]dihydropyridines of the formula (I):

wherein: (a) R1, R2, R3, R4 and R5 are taken independently among group consisting of hydrogen atom (H), halogen atom, nitro-group (NO2); (b) R6 is taken among group consisting of unbranched or branched (C1-C5)-alkyl wherein indicated alkyl can be substituted with phenylacetyloxy-, hydroxy- carboalkoxy-group or group NR'R'' wherein R' and R'' are taken independently among group consisting of hydrogen atom (H), unbranched or branched (C1-C8)-alkyl, benzyl; (c) R7 is taken among group consisting of hydrogen atom (H), alkyl; (d) R9 represents oxygen atom; (e) n is a whole number from 1 to 2, or its pharmaceutically acceptable salt. Compounds are useful as antagonists of calcium channels and elicit cardiovascular, anti-asthmatic and anti-bronchoconstricting activity. Also, invention describes the pharmaceutical composition.

EFFECT: valuable medicinal properties of compounds and composition.

28 cl, 2 tbl, 3 ex

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RU 2 257 388 C2

Authors

Dodd Dzhon G.

Genri Dzhejms R.

Rupert Kennet K.

Bullington Dzhejms L.

Kholl Dehniel A.

Dates

2005-07-27—Published

2000-06-23—Filed

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