FIELD: medicine.
SUBSTANCE: new derivatives of diphenyl urea having general formula I 
or their pharmaceutically comprehensible salts, where Ro - hydrogen are described; Rm - hydrogen or trifluoromethyl; Rp - hydrogen, halogeno, trifluoromethyl, trifluoromethoxy, C1-6alkyl or C1-6alkoxy; provided that Ro, Rm and Rp simultaneously cannot mean hydrogen; R2, R3, R4 and R5 independently mean hydrogen, halogeno or trifluoromethyl, provided that the bond does not represent N-(3-trifluoromethyl-phenyl)-N'-[3-(1N-tetrazole-5-il)-4'-trifluoromethyl-biphenyl-4-il]-urea, a pharmaceutical composition, their containing, and their application as blockers of chloride channels.
EFFECT: rising of efficiency of a composition and its application in medicine.
12 cl, 3 ex, 1 tbl
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