2-(PHENYL OR PYRID-3-YL)AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF LEUCINE-RICH REPEATING KINASE 2 (LRRK2) FOR TREATMENT OF PARKINSON'S DISEASE Russian patent published in 2018 - IPC C07D403/12 C07D401/14 C07D417/14 C07D413/14 C07D413/12 A61K31/506 A61P25/16 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to novel compounds of formula I or pharmaceutically acceptable salts thereof. In formula

I

m is 0 or 1; X is -NRa-; Ra is hydrogen; Y is C or N; R¹ is C_1-6-alkyl; R² is halogen or halogen-C_1-6-alkyl; R³ and R⁴ each independently represents a halogen, C_1-6-alkyl or C_1-6-alkoxy group; R⁵ is a 5-membered heteroaryl group containing ring heteroatoms 1–4 selected from nitrogen, oxygen and sulfur optionally substituted by one or more R⁶; and R⁶ represents: C_1-6-alkyl; halogen; halogen-C_1-6-alkyl; C_1-6-alkoxy group; 4-6-membered saturated heterocyclyl with an oxygen atom as a heteroatom; methoxymethyl or -C(O)-NRbRc, wherein Rb and Rc are each independently hydrogen or -C_1-6-alkyl.

EFFECT: compounds possess properties of a modulator of activity of leucine-rich re-kinase 2 (LRRK2) and can be used for use in the prevention or treatment of Parkinson's disease.

21 cl, 3 tbl, 14 ex