3-AMINO-PYRIDINE DERIVATIVES FOR TREATING METABOLIC DISORDERS Russian patent published in 2012 - IPC C07D401/12 A61K31/4709 A61K31/4725 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention describes novel compounds of general formula where Ar is part of quinoline or isoquinoline, which is substituted or unsubstituted; B is -O-; R¹ is hydrogen or S(O)₂R⁴; R² is S(O)₂R⁴, C(O)OR⁵ or C(O)(CH₂)_n-C(O)OR⁶; R³ is halogen; R⁴ is an aryl which is unsubstituted or optionally has up to five identical or different substitutes selected from a group consisting of halogen, alkyl, fluoroalkyl, hydroxyl, alkoxy, trifluoromethoxy, cyano, amide, CH₃CONH-, acyl and carboxyl; R⁵ is phenyl; R⁶ is hydrogen; n is an integer from 1 to 3; and a pharmaceutically acceptable salt or solvate. Also described is a method of producing compounds of formula (I) and pharmaceutical compositions containing said compounds, and also a method of treating metabolic disorders associated with resistance to insulin and hyperglycaemia and use of compounds of formula (I) to prepare a medicinal agent for treating metabolic disorders.

EFFECT: novel compounds which are suitable for treating metabolic disorders associated with resistance to insulin or hyperglycaemia are obtained and described.

28 cl, 54 ex, 4 tbl