FIELD: nanotechnologies; pharmaceutics.
SUBSTANCE: invention is related to food and pharmaceutical industry, namely to solid nanocompositions. Invention Solid nanocomposition contains 0.1-15% of active component, 40-95% of polymer, 0-6% hydrophobic or inertial polymer and 0-56% water-soluble component, at that nanocomposition on the basis contains taxipholin as active component, 40-95% of polymer, such as arabinogalactan or polyethylene glycols or polyvinyl pyrrolidones or polyvinyls of different molecular weights, and also 0-56% of water soluble polymer selected from row of possible fillers: kollidon VA64 (copolymer of vinylpyrrolidone and vinyl acetate), ludipress (modified lactose), kollidon 90F (high molecular polyvinyl pyrrolidone with molecular weight of 1000000- 1500000), sugar powder, isomaltose, 0-6% of hydrophobic or inertial polymer, where hydrophobic component contained by nanocomposition is compritol 888 ATO, (composition of mono-, di- and triglycerides of behenic acid), and inertial component is kollidon SR, Bast (mixture of polymers of polyvinyl pyrrolidone and polyvinyl acetate).
EFFECT: provides for higher bioavailability of active substances introduced in nanocomposition at creation of solid dosed forms with controlled release.
4 cl, 16 ex, 6 dwg
Title | Year | Author | Number |
---|---|---|---|
NANODISPERSE COENZYME Q10 COMPOSITION AND METHOD FOR MAKING THEREOF | 2009 |
|
RU2411027C1 |
SUPRAMOLECULAR COMPLEX, POSSESSING ANTI-INFLAMMATORY AND ANGIOPROTECTIVE ACTIVITY AND METHOD OF OBTAINING THEREOF | 2013 |
|
RU2533231C1 |
WATER-SOLUBLE COMPOSITION, POSSESSING ANTI-TUMOUR ACTIVITY AND METHOD FOR OBTAINING THEREOF | 2015 |
|
RU2611362C1 |
PHARMACEUTICAL COMPOSITION WITH PROLONGED RELEASE WITH ANTIPSYCHOTIC ACTIVITY AND SYNTHESIS METHODS THEREOF | 2012 |
|
RU2584653C2 |
METHOD OF ACETYLSALICYLIC ACID PREPARATION PREPARING | 1992 |
|
RU2054939C1 |
SOLID DISPERSION OF PAROXETINE (VARIANTS), METHOD FOR ITS OBTAINING (VARIANTS), METHOD FOR TREATING DEPRESSION IN A WARM-BLOODED ANIMAL | 1998 |
|
RU2185820C2 |
COMPOSITION OF BETULIN AND BIOCOMPATIBLE CARRIERS AND METHOD FOR MAKING THEREOF | 2009 |
|
RU2401118C1 |
POWDERS FOR PREPARING LIQUID DOSAGE FORM | 2008 |
|
RU2477133C2 |
METHOD OF PRODUCING A MEDICAMENT FOR TREATMENT OF CELIAC DISEASE AND A MEDICAMENT OBTAINED BY THIS METHOD | 2017 |
|
RU2674763C1 |
AGENT FOR TREATMENT OF DISEASES CAUSED BY MICROORGANISMS AND PROTOZOA | 1998 |
|
RU2196571C2 |
Authors
Dates
2009-04-10—Published
2007-04-09—Filed