NOVEL FUSIDIC ACID DERIVATIVES Russian patent published in 2009 - IPC C07J9/00 C07J13/00 A61K31/575 A61P31/04 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to novel fusidic acid derivatives of general formula [I], where X represents halogen, trifluoromethyl, C₁-C₇alkyl, substituted with phenyl, C₂-C₉alkenyl, optionally substituted with C₁-C₇alkyl, halogen or phenyl, phenyl, optionally substituted with one or two similar or different substituents, selected from group consisting of halogen, C₁-C₇alkyl, C₂-C₉alkenyl, phenyl, C₁-C₆alkoxy, nitro, C₁-C₆alkyltio, trifluoromethyl and cyano; or X represents naphtyl; Y and Z both represent hydrogen or together with bond C-17/C-20 form double bond between C-17 and C-20 or together represent methylene and form cyclopropane ring in combination with C-17 and C-20; A represents O, S or S(O); B represents C_1-6alkyl, C_2-6alkenyl, C_1-6acyl, phenyl or benzoyl, where C_1-6alkyl is optionally substituted with one or more halogens, hydroxy, C_2-6alkenyl, phenyl, C_1-4heteroaryl or C_1-6alkoxy; Q₁ represents -(CHOH)-, or -(CHW)-, where W represents halogen or azido; Q₂ represents -(CHOH)-; to their pharmaceutically acceptable salts and easily hydrolysed esters and to pharmaceutical compositions, including said derivatives, as well as to their application in therapy.

EFFECT: application in therapy.

31 cl, 127 ex, 5 tbl