NOVEL DERIVATIVES OF AMINOBENZOPHENONE Russian patent published in 2010 - IPC C07C225/22 C07C275/40 A61K31/136 A61P27/02 A61P35/00 

FIELD: chemistry.

SUBSTANCE: in the compound of general formula R₁ represents halogen, C_1-4alkyl, or C_1-4alkoxy; R₂ represents hydrogen, halogen; R₃ represents hydrogen, or one or several halogens; R₄ represents hydrogen, halogen, R₈ or Y₁R₈; Y₁ represents -NR_a-; R_a and R_b are similar or different, and each represents hydrogen or C_1-4alkyl; R₈ represents hydrogen, C_1-10alkyl; R₇ represents hydrogen, hydroxy, trifluoromethyl, amino, C_1-6hydroxyalkyl, C_1-4alkoxy, C_1-4alkylthio, C_1-6alkylamino, C_1-4alkoxycarbonyl, -S(O)₂R, -COOH, -CONH₂, or -NR_aC(O)R', where R and R' are similar or different, and each represents hydrogen or C_1-3alkyl; R₅ represents -COOH, Y₂R₉, Y₂R₉Y₃R₁₀, C_1-6alkyl-Y₂R₉, C_1-10alkyl, or unsaturated C_3-8carbocycle, said R₅ is substituted with one or several, similar or different substituents, represented by R₇; R₆ represents hydrogen; Y₂ represents -O-, -NR_a-, -NR_aC(O)NR_b-, -NR_aC(O)-, -C(O)NR_a-, -C(O)-, -NR_aC(O)O-, or -OC(O)-; R₉ represents C_1-10alkyldioxolanyl, C_1-10alkylthiazolyl, C_1-10alkylmorpholinyl, etc.

EFFECT: obtaining novel compounds, represented by formula I, which possess properties of TNF-α or MAP-kinase p38a inhibitors for obtaining medication to be applied as anti-inflammatory or anti-cancer agent.

24 cl, 4 tbl, 270 ex