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(19)

(11)

2 355 704

(13)

(51)

IPC

C07K16/12(2006-01-01)

C12P21/00(2006-01-01)

G01N33/53(2006-01-01)

(21) (22)

Application

2006146886/13, 2002-04-11

(24)

Start date

2002-04-11

(22)

Actual filing date

2002-04-11

(45)

Published

2009-05-20

(72)

Inventor

Granoff DehnMoeh GregoriRappuoli Rino

(73)

Holder

Novartis Vehksins Ehnd Diagnostiks, InkChildren`Z Khospital Oklend Riserch Instit'Jut

MONOCLONAL ANTIBODY DIRECTED AGAINST GNA33 PEPTIDE AND ITS APPLICATION Russian patent published in 2009 - IPC C07K16/12 C12P21/00 G01N33/53

Abstract RU 2355704 C2

FIELD: medicine.

SUBSTANCE: invention describes monoclonal antibody directed against GNA33 peptide with definite amino acid sequence, which demonstrates complement-mediated bactericidal and/or opsonic activity against bacteria Neisseria meningitides of serogroup B (MenB). On the basis of monoclonal antibody composition for treatment and prevention of MenB disease has been constructed, and application of composition favours production of immune response against said bacteria after its introduction into organism of subject-mammal. According to invention monoclonal antibody can also be used for isolating molecular mimetic of epitope of bacteria Neisseria meningitides of serogroup B (MenB) by antibody contact with supposed mimetic and isolation of formed antibody-mimetic complex.

EFFECT: according to invention antibodies and based on them compositions can be efficiently used for prevention of MenB disease, as well as for diagnostics of MenB infection.

5 cl, 9 dwg, 6 tbl, 5 ex

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RU 2 355 704 C2

Authors

Granoff Dehn

Moeh Gregori

Rappuoli Rino

Dates

2009-05-20—Published

2002-04-11—Filed