FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry. Disclosed is a polypeptide essentially consisting of amino acid sequence SEQ ID NO: 23 for inducing immune response in a mammal against meningococcal bacteria. Provided is a nucleic acid which codes said polypeptide. The invention also provides a plasmid which contains a nucleotide sequence and a host cell which is transformed by said plasmid, which are meant for expressing said polypeptide. Provided is a membrane vesicle containing the polypeptide for use as a medicament for preventing meningococcosis in a mammal. Disclosed is an immunogenic composition which contains an effective amount of the polypeptide or vesicle.
EFFECT: invention enables to induce immune response in a mammal against meningococcal bacteria.
14 cl, 5 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| MENINGOCOCCAL fHBP POLYPEPTIDES | 2012 |
|
RU2567003C2 |
| VACCINES FOR SEROGROUP X MENINGOCOCCUS | 2013 |
|
RU2644340C2 |
| COMBINATIONS OF MENINGOCOCCAL FACTOR-H-BINDING PROTEIN AND PNEUMOCOCCAL SACCHARIDE CONJUGATES | 2010 |
|
RU2555757C2 |
| FACTOR H-BINDING ADJUVANT MENINGOCOCCAL PROTEIN | 2010 |
|
RU2557315C2 |
| COMBINATIONS CONTAINING SEROTYPE 14 PNEUMOCOCCAL SACCHARIDE | 2010 |
|
RU2549438C2 |
| LIQUID VACCINES FOR MULTIPLE MENINGOCOCCAL SEROGROUPS | 2004 |
|
RU2378010C2 |
| MULTIPLE VERSIONS OF MENINGOCOCCAL PROTEIN NMB 1870 | 2003 |
|
RU2336091C2 |
| LIQUID VACCINE FOR MULTIPLE SEROGROUPS OF MENINGOCOCCUS | 2009 |
|
RU2595845C2 |
| NEISSERIA MENINGITIDIS COMPOSITIONS AND METHODS OF USE THEREOF | 2013 |
|
RU2665841C2 |
| KIT FOR PREPARING IMMUNOGENIC COMPOSITION FOR SEROGROUP B Neisseria meningitidis | 2008 |
|
RU2498815C2 |
