FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biochemistry, particularly to a polypeptide containing the amino acid sequence SEQ ID NO: 20 eliciting a mammalian immune response to meningococcal bacteria. What is presented is a nucleic acid coding the above polypeptide. There are presented a plasmid containing the above nucleotide sequence, and a host cell transformed by the above plasmid; both plasmid, and host cell are applicable for expression of this polypeptide. What is presented is a membrane vesicle comprising the above polypeptide applicable as a medicinal product for preventing meningococcal infection in a mammal. What is disclosed is an immunogenic composition containing an effective amount of the polypeptide or vesicle.
EFFECT: invention enables effectively eliciting the mammalian immune response to meningococcal bacteria.
14 cl
| Title | Year | Author | Number |
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