TETRAHYDRO-NAPHTHYRIDINE DERIVATIVES AND METHOD OF THEIR OBTAINING Russian patent published in 2009 - IPC C07D471/04 C07D491/48 C07D491/56 A61K31/4375 A61K31/496 A61K31/497 A61K31/5377 

FIELD: pharmacology.

SUBSTANCE: invention relates to novel compounds - tetrahydronaphthyridine derivatives of formula (I) or their pharmaceutically acceptable salts, where R¹ represents C₁-₆alkoxycarbonyl group optionally substituted with 1-5 substituents, etc; R² represents C_1-6alkyl group; R³ represents hydrogen or and all; R⁴ represents C_1-4alkylene group; R⁵ represents optionally substituted unsaturated 5-8-member heterocyclic group containing 1-4 heteroatoms independently selected from oxygen and nitrogen atoms; R⁶, R⁷ and R⁸ represent independently hydrogen atom, hydroxygroup, cyanogroup, C_1-6alkyl group, C_1-6alkoxygroup, mono- or di- C_1-6alkylcarbamoyl group or mono- or di- C_1-6alkylaminogroup, optionally substituted with 1-6 substituents independently selected from halogen atom, C_1-6alkoxygroup and aminogroup; R¹⁰ represents optionally substituted with 1-2 substituents phenyl group; which possess inhibiting activity with respect to cholesteryl ester transfer protein (CETP).

EFFECT: novel tetrahydronaphthyridine derivatives and method of obtaining them.

12 cl, 408 ex, 38 tbl