FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a compound of formula I, where R1, R2, R3, X1, Y1, Y2, Y3, Y4 and Y5 have the meanings defined in this use, and a pharmaceutically acceptable salt thereof, as antagonist of MC4R. Pharmaceutical compositions containing such compounds and salts, and the use of such compounds and salts for the treatment of, for example, cachexia, anorexia or anorexia nervosa are also provided.
EFFECT: obtaining spiro compounds as antagonists of melanocortin 4 receptors and their use.
20 cl, 6 dwg, 14 tbl, 201 ex
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