TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS Russian patent published in 2014 - IPC C07D471/06 C07D471/16 C07D487/06 C07D519/00 A61K31/437 A61K31/4375 A61K31/4985 A61K31/536 A61P31/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to a compound of formula (I)_CE, wherein "-----" means a bond, V represents CH, and U represents CH or N, or "-----" means a bond, V represents CR⁶ and U represents CH, or also "-----" means a bond, V represents N and U represents CH, or "-----" is absent, V represents CH, and U represents CH₂, NH or NR⁹; R⁰ represents H, or provided "-----" means a bond, can also represent C_1-3alkoxygroup; R¹ represents H, halogen, cyanogroup, C_1-3alkyl or ethinyl; R² represents H, acetyl or a group of formula -CH₂-R³; R³ represents H, C_1-3alkyl or C_1-3hydroxyalkyl; R⁴ represents H, or provided n is other than 0, and R⁵ means H, can also represent OH; R⁵ represents H, C_1-3alkyl, C_1-3hydroxyalkyl, C_1-3aminoalkyl, C_1-3alkoxyC_1-3alkyl, carboxyl group or C_1-3alkoxycarbonyl; R⁶ represents C_1-3hydroxyalkyl, carboxyl group, C_1-3alkoxycarbonyl or a group -(CH₂)_q-NR⁷R⁸, wherein q is 1, 2 or 3 and each of R⁷ and R⁸ independently represents H or C_1-3alkyl, or R⁷ and R⁸ together with a nitrogen atom to which they are attached, form a pyrrolodinyl or piperidinyl ring; R⁹ represents C_1-3alkyl, 2-hydroxyethyl, 2-hydroxypropyl or 3-hydroxypropyl; A represents -(CH₂)_p-, -CH₂CH₂CH(OH)- or -COCH₂CH(OH)-; G represents a phenyl group which is mono- or disubstituted in m- and/or n-position(s)by substitutes independently specified C_1-4alkyl, C_1-3alkoxygroup and halogen, or G means a group of one of formulas below G¹ and G², wherein Q means O or S, and X means CH or N; and each Y¹, Y² and Y³ represents CH, or one of Y¹ and Y³ represents N, and the other one represents CH; and n is equal to 0, provided A represents -CH₂CH₂CH(OH)- or -COCH₂CH(OH)-, and n is equal to 0, 1 or 2, provided A represents (CH₂)_p, wherein p is equal to 1, 2, 3 or 4, provided a sum of n and p is then equal to 2, 3 or 4; or a pharmaceutically acceptable salt of this compound.

EFFECT: compound of formula (I)_CE or its pharmaceutically acceptable salt are applicable as a therapeutic agent for preventing or treating a bacterial infection.

29 cl, 2 tbl, 202 ex