PRODUCTION AND APPLICATION OF ARYLALKYL DERIVATIVE ACIDS FOR OBESITY TREATMENT Russian patent published in 2009 - IPC C07D235/30 C07D277/82 C07D277/42 C07D277/58 C07D263/58 A61K31/4184 A61K31/423 A61K31/428 A61K31/426 A61P3/04 

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of formula (I) and its pharmaceutically acceptable salts and esters. Compounds of the present invention are characterised with properties of DGAT-1 inhibitor. In general formula (I) , Q represents O, S or NR⁵; A represents a linker chosen from where p is equal to 1 or 2, and , where m is equal to 0, and n is equal to 1, 2, 3 or 4, or m is equal to 1, while n is equal to 1, 2 or 3, where specified linker is optionally substituted with one or two groups R⁸; R¹ and R² are independently chosen from hydrogen, haloid; R³ is chosen from hydrogen, (C₁-C₆)alkyl optionally substituted with hydroxyl and phenyl optionally substituted with haloid; R⁴ is chosen from hydrogen, nitro and (C₁-C₆)alkyl; or R³ and R⁴ together with carbon atoms whereto attached, can form benzene ring optionally substituted with 1-2 substitutes. The invention also concerns compounds of formula (Ia) and (Ib) with structural formulas presented in the patent claim, and also to a pharmaceutical composition, a medical product, to application of compounds for making a medical product and compound process.

EFFECT: new compounds possess useful biological activity.

19 cl, 2 tbl, 7 dwg, 215 ex