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(19)

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2 357 964

(13)

(51)

IPC

C07D401/04(2006-01-01)

C07D403/04(2006-01-01)

A61K31/4184(2006-01-01)

A61K31/4025(2006-01-01)

A61P29/02(2006-01-01)

A61K31/397(2006-01-01)

A61K31/4523(2006-01-01)

A61K31/517(2006-01-01)

(21) (22)

Application

2006110519/04, 2004-10-01

(24)

Start date

2004-10-01

(22)

Actual filing date

2004-10-01

(45)

Published

2009-06-10

(72)

Inventor

Den Khartog Jakobus A. J.David Samuehl'Zhasseran Daniehl'Van Skharrenburg Gjustaf J. M.Van Stejvenberg Kherman Kh.Tejnstra Tinka

(73)

Holder

Solvej Farmas'Jutikals B.V.

BICYCLO-3,1,1-HEPTANE-SUBSTITUTED BENZIMIDAZOLONE- AND QUINAZOLINONE-DERIVATIVES AS AGONISTS OF HUMAN ORL1 RECEPTORS Russian patent published in 2009 - IPC C07D401/04 C07D403/04 A61K31/4184 A61K31/4025 A61P29/02 A61K31/397 A61K31/4523 A61K31/517

Abstract RU 2357964 C2

FIELD: chemistry.

SUBSTANCE: invention refers to the group including hydronopol-substituted benzimidazolone- and quinazolinone-derivatives as agonists of human ORL1 receptors (nociceptors). In addition, the invention refers to making specified compounds, to pharmaceutical compositions containing pharmacologically active amount of at least one specified new benzimidazolone- and quinazolinone-derivatives as an active component, and to application of said pharmaceutical compositions in treatment of disorders involving ORL1 receptors. The invention concerns compounds of general formula where symbols take on values specified in the description.

EFFECT: higher effectiveness of the composition and therapy.

7 cl, 17 ex, tbl

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RU 2 357 964 C2

Authors

Den Khartog Jakobus A. J.

David Samuehl'

Zhasseran Daniehl'

Van Skharrenburg Gjustaf J. M.

Van Stejvenberg Kherman Kh.

Tejnstra Tinka

Dates

2009-06-10—Published

2004-10-01—Filed