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IPC

C07D233/90(2006-01-01)

C07D295/30(2006-01-01)

C07D401/12(2006-01-01)

C07D405/12(2006-01-01)

C07C257/18(2006-01-01)

A61K31/4164(2006-01-01)

(21) (22)

Application

2004111979/04, 2002-09-17

(24)

Start date

2002-09-17

(22)

Actual filing date

2002-09-17

(45)

Published

2007-05-20

(72)

Inventor

Krjuse Kornelis G.Lange Josefus Kh. M.Kherremans Arnol'Dus Kh. J.Van Stejvenberg Kherman Kh.

(73)

Holder

Solvej Farmas'Jutikals B.V.

DERIVATIVES OF 1H-IMIDAZOLE POSSESSING CB-AGONISTIC, PARTIAL CB-AGONISTIC OR CB-ANTAGONISTIC ACTIVITY Russian patent published in 2007 - IPC C07D233/90 C07D295/30 C07D401/12 C07D405/12 C07C257/18 A61K31/4164

Abstract RU 2299200 C2

FIELD: organic chemistry, medicine.

SUBSTANCE: invention describes derivatives of 1H-imidazole-4-carboxamide of the formula (I): wherein R represents phenyl, 2-pyridinyl, 3-pyridinyl that can be substituted; R₁ means phenyl, 5-membered aromatic heterocyclic ring comprising one nitrogen atom (N) as a heteroatom that can be substituted; R₂ means hydrogen atom (H), (C₁-C₈)-alkyl; R₃ represents (C₂-C₈)-alkyl, (C₁-C₈)-alkoxy-group, (C₃-C₈)-cycloalkyl, benzyl group, aromatic ring that can be substituted; R₄ means hydrogen or halogen atom, cyano-group, sulfamoyl, methanesulfonyl, methylsulfanyl or (C₁-C₄)-alkyl. Also, invention describes methods for synthesis of these compounds and pharmaceutical compositions. Derivatives of 1H-imidazole-4-carboxamide are effective agonists, partial agonists or antagonists of cannabinoid CB₁-receptors that can be useful in treatment of psychic and neurological diseases and other diseases with involving cannabinoid neurotransmission.

EFFECT: valuable biological and medicinal properties of compounds and pharmaceutical compositions.

11 cl, 1 tbl, 113 ex

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RU 2 299 200 C2

Authors

Krjuse Kornelis G.

Lange Josefus Kh. M.

Kherremans Arnol'Dus Kh. J.

Van Stejvenberg Kherman Kh.

Dates

2007-05-20—Published

2002-09-17—Filed