SPIROCYCLIC CYCLOHEXANE DERIVATIVES Russian patent published in 2012 - IPC C07D471/10 C07D491/107 C07D495/10 A61K31/407 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel spirocyclic cyclohexane derivatives of formula I: , where: R¹ and R² together form a ring and are -CH₂CH₂CH₂-; R³ denotes a saturated, branched or straight, unsubstituted C_1-5-alkyl; unsubstituted or monosubstituted with F, Cl, Br, I phenyl; 5-member heteroaryl containing sulphur as a heteroatom; unsubstituted or monosubstituted with F, Cl, Br, I phenyl, attached through a C_1-3-alkyl group; R⁵ denotes H; R⁶ denotes H, F, Cl; R⁷, R⁸, R⁹ and R¹⁰ independently denote H, F, Cl, Br, I; X denotes O, NR¹⁷; R¹⁷ denotes H, COR¹²; R¹² denotes H, unsaturated, branched or straight, unsubstituted or phenyl-substituted C_1-5-alkyl; in form of a racemate; enantiomers, diastereomers, mixtures of enantiomers or diastereomers, or a separate enantiomer or diastereomer; bases and/or salts of physiologically compatible acids or cations.

EFFECT: compounds have binding action on the ORL1 receptor and the µ-opioid receptor, which enables their use to treat various diseases.

12 cl, 11 ex