FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to neonatology. Method of late neonatal sepsis prediction in premature infants involves estimation of informative signs within the first 4-6 days of life. Diagnostic factors are specified for each sign with informativity decrease: observed recovery of complete parenteral nutrition allows for diagnostic factor 0.59. If complete parenteral nutrition is not recovered, diagnostic factor (-)0.54 is specified. Concentration of standard bicarbonates in capillary blood >21 mmol/l ensures diagnostic factor 0.37, while concentration of standard bicarbonates in capillary blood ≤21 mmol/l shows diagnostic factor (-)0.59. Observed intraventricular hemorrhages of degree 3-4 show diagnostic factor being 0.54. In case intraventricular hemorrhages of degree 3-4 are not observed, diagnostic factor is (-)0.23; average indicator of oxygen saturation >70% provides diagnostic factor (-)0.19, while average indicator of oxygen saturation ≤70% indicates diagnostic factor 0.63. Indicator of erythrocyte volume distribution >16% allows for diagnostic factor 0.36, and with this indicator ≤16%, diagnostic factor is (-)0.31. Breast feeding ensures diagnostic factor (-)0.46, while artificial or mixed feeding provides diagnostic factor 0.18; in monocyte fraction >16%, diagnostic factor is 0.07, while in monocyte fraction ≤16% diagnostic factor is (-)0.12. Then diagnostic factors (DF) are summed starting with correction (-)0.129, and the patient is considered to be referred to the group of potential development of late neonatal sepsis if total diagnostic factors in informativity decreasing order at certain analysis stage is equal or exceeds upper threshold 0.68. The patient is referred to the group of absent data specifying development of late neonatal sepsis if total diagnostic factors are equal or less than lower threshold (-)1.2. Method provides integrated estimate approach and multifactorality of late neonatal sepsis development at premature infants.
EFFECT: accurate prediction allows reducing probability of lethal outcomes due to early change of therapeutic tactics.
1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PERIVENTRICULAR LEUKOMALACIA DIAGNOSIS OF INFANCY WITH ISCHEMIC CEREBRAL AFFECTION | 2006 |
|
RU2325841C1 |
| RETINOPATHY STAGE IV-V DIAGNOSTIC TECHNIQUE IN PREMATURE INFANTS | 2007 |
|
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| SPASTIC INFANTILE CEREBRAL PARALYSIS PREDICTION FOR PREMATURE CHILDREN | 2006 |
|
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| METHOD OF FORECASTING INFINTILE CEREBRAL PARALYSES IN MATURE BABIES | 2007 |
|
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| PREDICTION METHOD OF PREMATURE RETINOPATHY LASER COAGULATION USE | 2016 |
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| METHOD OF NEUROLOGIC DIAGNOSIS PREDICTION IN 2-YEAR-OLD CHILDREN WITH PREVIOUS CRITICAL CONDITION IN EARLY NEONATAL PERIOD | 2007 |
|
RU2336026C1 |
| METHOD FOR EARLY PREDICTION OF CYSTIC PERIVENTRICULAR LEUKOMALACIA IN NEWBORNS WITH VERY LOW OR EXTREMELY LOW BODY WEIGHT | 2014 |
|
RU2557881C1 |
| METHOD OF PREDICTING DEVELOPMENT OF EARLY NEONATAL SEPSIS IN NEWBORNS WHOSE MOTHERS HAD COVID-19 DURING PREGNANCY | 2023 |
|
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| METHOD FOR PREDICTING THE RISK OF INTESTINAL COLONIZATION BY KLEBSIELLA PNEUMONIAE IN PRETERM INFANTS IN THE NEONATAL PERIOD | 2022 |
|
RU2793050C1 |
| METHOD OF PREDICTING MORTALITY IN NEWBORNS WHOSE MOTHERS HAD COVID-19 DURING PREGNANCY | 2023 |
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RU2800892C1 |
