METHOD OF PREDICTING MORTALITY IN NEWBORNS WHOSE MOTHERS HAD COVID-19 DURING PREGNANCY Russian patent published in 2023 - IPC A61B5/00 G01N33/49 

FIELD: medicine, neonatology, pediatrics, anesthesiology and resuscitation, obstetrics and gynecology.

SUBSTANCE: following comprehensive assessment of the mother's medical history is performed: past infection with COVID-19 within 3 weeks or less before delivery, course of labor: premature rupture of amniotic fluid, and clinical and laboratory data of the newborn on the first day of life: anemia, fetal growth retardation syndrome, respiratory support in the form of artificial ventilation of the lungs, the gestational age of the child. The diagnostic index (DI) is calculated by the following formula: DI = 2,878 Х1 – 2,899 Х2– 4,856 Х3 – 5,413 Х4 – 2,740 Х5 + 0,479 Х6 – 9,597, where: X1 is severe anemia in a newborn, if present — 1, if absent — 0; X2 is a syndrome of fetal growth retardation, if present — 1, if absent — 0; X3 is past COVID-19 in the mother within 3 weeks before delivery, if present — 1, if absent — 0; X4 is premature rupture of amniotic fluid, if present — 1, if absent — 0; X5 is respiratory support in the form of artificial lung ventilation, if present — 1, if absent — 0; X6 is gestational age, weeks. When DI exceeds 0, a conclusion is made that there are no risks of a lethal outcome, and when DI is less than 0, a high risk of neonatal mortality is predicted.

EFFECT: method allows to predict a lethal outcome in newborns born in serious condition and observed in the intensive care unit, those, whose mothers had COVID-19 infection during pregnancy, with a specificity of 89.7%, a sensitivity of 80.0% and an efficiency of 84.9% and optimize the tactics of managing this category of children.

1 cl, 2 ex