SORBENT FOR ANTIBODY REMOVAL FROM WHOLE BLOOD AND METHOD FOR MAKING THEREOF Russian patent published in 2009 - IPC A61M1/38 A61K39/00 

FIELD: medicine.

SUBSTANCE: sorbent for antibody removal from whole blood includes microspheres sized 0.2-1.2 mm consisting of antigen and alginic acid or calcium alginate enclosed in a semipermeable membrane made of polycationic polymer passing proteins of molecular weight 1000 kDa and less. As a polycationic polymer, the sorbent can contain either chitosan, or poly-L-lysine, or poly-L-arginine. Herewith the antigen represents a high-molecular water-soluble polymer conjugate with saccharide. Polymer represents either polyacrylamide, or polyacrylic acid, or their copolymer, or chitosan. Besides, saccharide can represent oligosaccharide of blood group A or B, or oligosaccharide component of ganglioside or sulphated glycolipid, or tumour-associated oligosaccharide. The method for making the sorbent involves injection of sodium alginate solution drops and antigen into calcium salt solution. The prepared material is kept in polycationic polymer solution to form microspheres then to be processed with complexon, e.g. ethylenediamine tetraacetate (EDTA), to remove calcium ions.

EFFECT: improved effectiveness.

6 dwg, 5 tbl, 17 ex, 10 cl